Monograph: Afatinib Dimaleate

Afatinib Dimaleate

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Full Title

Afatinib Dimaleate

Generic Name

Afatinib Dimaleate

Chemical Name

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INV Number

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Classification

CAS Number

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Introduction

Introduction

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Description

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Uses

Uses

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Non-small Cell Lung Cancer

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First-line Therapy for Metastatic Non-small Cell Lung Cancer

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Previously Treated Metastatic Non-small Cell Lung Cancer

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Dosage and Administration

Dosage and Administration

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General

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Administration

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Dosage

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Non-small Cell Lung Cancer

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Dosage Modification

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Grade 3 or 4 Toxicity

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Diarrhea

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Dermatologic Toxicity

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Nephrotoxicity

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Concomitant Use with Drugs Affecting the P-glycoprotein Transport System

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Special Populations

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Cautions

Cautions

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Contraindications

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Warnings/Precautions

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Diarrhea

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Dermatologic Effects

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Pulmonary Effects

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Hepatic Toxicity

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Ocular Effects

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Fetal/Neonatal Morbidity and Mortality

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Cardiovascular Effects

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Impairment of Fertility

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Specific Populations

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Pregnancy

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Lactation

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Pediatric Use

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Geriatric Use

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Hepatic Impairment

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Renal Impairment

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Common Adverse Effects

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Drug Interactions

Drug Interactions

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Drugs Affecting Hepatic Microsomal Enzymes

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Drugs Metabolized by Hepatic Microsomal Enzymes

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Drugs Affecting the P-glycoprotein Transport System

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Inhibitors of P-gp

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Inducers of P-gp

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Antineoplastic Agents

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Cisplatin

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Paclitaxel

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Fluorouracil

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Advice to Patients

Advice to Patients

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Preparations

Preparations

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Afatinib Dimaleate

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Common general statement Elements

Additional Information

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2019, Selected Revisions July 1, 2019. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

Quelle

AHFS Drug Information