Monograph: Denosumab

Denosumab

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Full Title

Denosumab

Generic Name

Denosumab

Chemical Name

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INV Number

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Classification

CAS Number

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Introduction

Introduction

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Description

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Uses

Uses

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Osteoporosis

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Treatment in Postmenopausal Women at High Risk for Fracture

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Clinical Experience

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Treatment in Men at High Risk for Fracture

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Clinical Experience

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Glucocorticoid-induced Osteoporosis

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Clinical Experience

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Bone Loss Associated with Androgen Deprivation Therapy

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Treatment in Men with Nonmetastatic Prostate Cancer at High Risk for Fracture

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Clinical Experience

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Bone Loss Associated with Aromatase Inhibitor Therapy

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Treatment in Women with Breast Cancer at High Risk for Fracture

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Clinical Experience

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Multiple Myeloma and Bone Metastases of Solid Tumors

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Prevention of Skeletal-related Events

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Clinical Experience

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Giant Cell Tumor of Bone

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Clinical Experience

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Hypercalcemia Associated with Malignancy

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Dosage and Administration

Dosage and Administration

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Administration

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Dosage

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Osteoporosis

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Treatment in Postmenopausal Women at High Risk for Fracture

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Treatment in Men at High Risk for Fracture

...

Glucocorticoid-induced Osteoporosis

...

Bone Loss Associated with Androgen Deprivation Therapy

...

Treatment in Men with Nonmetastatic Prostate Cancer at High Risk for Fracture

...

Bone Loss Associated with Aromatase Inhibitor Therapy

...

Treatment in Women with Breast Cancer at High Risk for Fracture

...

Multiple Myeloma and Bone Metastases of Solid Tumors

...

Prevention of Skeletal-related Events

...

Giant Cell Tumor of Bone

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Hypercalcemia Associated with Malignancy

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Special Populations

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Cautions

Cautions

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Contraindications

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Warnings/Precautions

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Choice of Denosumab Products

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Fetal/Neonatal Morbidity and Mortality

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Sensitivity Reactions

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Hypersensitivity

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Latex Sensitivity

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Hypocalcemia and Mineral Metabolism

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Osteonecrosis of the Jaw

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Atypical Subtrochanteric and Diaphyseal Femoral Fracture

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Hypercalcemia Following Discontinuance of Therapy

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Multiple Vertebral Fractures Following Discontinuance of Therapy

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Serious Infections

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Dermatologic Reactions

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Musculoskeletal Pain

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Suppression of Bone Turnover

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Immunogenicity and Antibody Formation

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Specific Populations

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Pregnancy

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Lactation

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Pediatric Use

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Geriatric Use

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Hepatic Impairment

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Renal Impairment

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Common Adverse Effects

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Drug Interactions

Drug Interactions

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Drugs Metabolized by Hepatic Microsomal Enzymes

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Drugs Affecting Serum Calcium Concentrations

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Antineoplastic Agents

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Etanercept

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Immunosuppressive Agents

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Midazolam

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Advice to Patients

Advice to Patients

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Preparations

Preparations

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Denosumab

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Common general statement Elements

Additional Information

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REMS

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2019, Selected Revisions August 26, 2019. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

Quelle

AHFS Drug Information