Monograph: Ganciclovir Sodium

Ganciclovir Sodium

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Full Title

Ganciclovir Sodium

Generic Name

Ganciclovir Sodium

Chemical Name

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INV Number

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Synonym

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Classification

CAS Number

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Introduction

Introduction

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Uses

Uses

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Treatment of Cytomegalovirus Infection and Disease

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Cytomegalovirus Retinitis

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Clinical Experience

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Extraocular Cytomegalovirus Infections

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GI Infections

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Pneumonitis

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Neurologic Disease

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Congenital Cytomegalovirus Disease

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Prevention of Cytomegalovirus Infection and Disease

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Clinical Experience

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Varicella-Zoster Virus Infections

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Dosage and Administration

Dosage and Administration

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Reconstitution and Administration

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IV Infusion

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Rate of Administration

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Dosage

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Adult Dosage

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Cytomegalovirus Retinitis

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Cytomegalovirus Esophagitis or Colitis

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Cytomegalovirus Pneumonitis

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Cytomegalovirus Neurologic Disease

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Prevention of Cytomegalovirus Infection and Disease in Transplant Recipients

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Varicella-Zoster Virus Infections

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Pediatric Dosage

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Cytomegalovirus Retinitis

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CNS or Disseminated Cytomegalovirus Infections

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Congenital Cytomegalovirus Disease

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Prevention of Cytomegalovirus Infection and Disease in Transplant Recipients

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Varicella-Zoster Virus Infections

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Dosage in Renal Impairment

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Table 1. Dosage of IV Ganciclovir for Management of CMV Retinitis in Adults with Renal Impairment1214

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Cautions

Cautions

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Hematologic Effects

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Ocular Effects

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Nervous System Effects

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GI Effects

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Renal and Genitourinary Effects

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Local Effects

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Other Adverse Effects

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Precautions and Contraindications

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Pediatric Precautions

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Geriatric Precautions

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Mutagenicity and Carcinogenicity

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Pregnancy, Fertility, and Lactation

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Pregnancy

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Fertility

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Lactation

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Drug Interactions

Drug Interactions

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Antibacterial Agents

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Imipenem and Cilastatin Sodium

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Trimethoprim

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Other Antibacterials

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Antifungal Agents

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Amphotericin B

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Flucytosine

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Antiretroviral Agents

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Didanosine

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Tenofovir

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Zidovudine

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Antiviral Agents

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Foscarnet

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Letermovir

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Immunosuppressive Agents

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Cyclosporine

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Mycophenolate Mofetil

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Tacrolimus

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Myelosuppressive Drugs

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Probenecid

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Acute Toxicity

Acute Toxicity

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Pharmacokinetics

Pharmacokinetics

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Absorption

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Distribution

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Elimination

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Chemistry and Stability

Chemistry and Stability

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Chemistry

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Stability

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Spectrum Section

Spectrum

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Resistance Section

Resistance

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Mechanism of Action

Mechanism of Action

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Preparations

Preparations

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Ganciclovir

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Ganciclovir Sodium

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2019, Selected Revisions August 12, 2019. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

† Use is not currently included in the labeling approved by the US Food and Drug Administration.

Quelle

AHFS Drug Information