Monograph: Atovaquone and Proguanil Hydrochloride

Atovaquone and Proguanil Hydrochloride

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Full Title

Atovaquone and Proguanil Hydrochloride

Generic Name

Atovaquone and Proguanil Hydrochloride; Atovaquone; Proguanil Hydrochloride

Chemical Name

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INV Number

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Synonym

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ATC-Code

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Classification

CAS Number

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Introduction

Introduction

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Description

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Uses

Uses

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Malaria

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Prevention of Malaria

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Clinical Experience

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Presumptive Self-treatment of Malaria

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Treatment of Uncomplicated Malaria

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Clinical Experience

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Dosage and Administration

Dosage and Administration

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Administration

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Dosage

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Prevention of Malaria

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Table 1. Pediatric Dosage of Atovaquone/proguanil for Prevention of Malaria1115121134

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Presumptive Self-treatment of Malaria

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Treatment of Uncomplicated Malaria

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Table 2. Pediatric Dosage of Atovaquone/proguanil for Treatment of Uncomplicated P. falciparum Malaria1134144

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Special Populations

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Renal Impairment

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Hepatic Impairment

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Cautions

Cautions

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Contraindications

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Warnings/Precautions

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Sensitivity Reactions

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GI Effects

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Hepatotoxicity

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Malaria Recrudescence

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Selection and Use of Antimalarials

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Specific Populations

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Pregnancy

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Lactation

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Pediatric Use

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Geriatric Use

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Hepatic Impairment

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Renal Impairment

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Common Adverse Effects

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Drug Interactions

Drug Interactions

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Drugs Affecting Hepatic Microsomal Enzymes

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Antimycobacterial Agents

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Antiretroviral Agents

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Metoclopramide

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Tetracycline

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Warfarin

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Pharmacokinetics

Pharmacokinetics

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Absorption

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Bioavailability

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Food

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Distribution

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Extent

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Plasma Protein Binding

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Elimination

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Metabolism

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Elimination Route

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Half-life

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Special Populations

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Advice to Patients

Advice to Patients

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Preparations

Preparations

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Atovaquone and Proguanil Hydrochloride

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Common general statement Elements

Additional Information

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2020, Selected Revisions March 4, 2014. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

† Use is not currently included in the labeling approved by the US Food and Drug Administration.

Quelle

AHFS Drug Information