Monograph: ARIPiprazole, ARIPiprazole Lauroxil

ARIPiprazole, ARIPiprazole Lauroxil

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Full Title

ARIPiprazole, ARIPiprazole Lauroxil

Generic Name

ARIPiprazole; ARIPiprazole Lauroxil

Chemical Name

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INV Number

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Classification

CAS Number

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Introduction

Introduction

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Description

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Aripiprazole Tablets with Sensor

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Uses

Uses

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Psychotic Disorders

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Schizophrenia

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Bipolar Disorder

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Major Depressive Disorder

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Irritability Associated with Autistic Disorder

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Tourette's Syndrome

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Agitation Associated with Schizophrenia or Bipolar Mania

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Dosage and Administration

Dosage and Administration

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Administration

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Oral Administration

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Orally Disintegrating Tablets

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Tablets with Sensor

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IM Administration

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Extended-release Aripiprazole Injection

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Extended-release Aripiprazole Lauroxil Injection

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Dosage

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Schizophrenia

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Oral Dosage

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IM Dosage of Aripiprazole (Abilify Maintena®)

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IM Dosage of Aripiprazole Lauroxil (Aristada®)

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Table 1. Recommended Oral Aripiprazole Supplementation Following Missed Doses of Extended-release Aripiprazole Lauroxil Injection (Aristada®).119

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Table 2. Recommended IM Aripiprazole Lauroxil Supplementation with Aristada Initio® Following Missed Doses of Extended-release Aripiprazole Lauroxil Injection (Aristada®).147

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IM Dosage of Aripiprazole Lauroxil (Aristada Initio®)

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Bipolar Disorder

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Oral Dosage

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IM Dosage of Aripiprazole

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Major Depressive Disorder

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Irritability Associated with Autistic Disorder

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Tourette's Syndrome

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Special Populations

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Pharmacogenomics and Poor CYP2D6 Metabolizer Phenotype

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Drugs Affecting Hepatic Microsomal Enzymes

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Cautions

Cautions

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Contraindications

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Warnings/Precautions

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Warnings

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Increased Mortality in Geriatric Patients with Dementia-related Psychosis

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Worsening of Depression and Suicidality Risk

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Sensitivity Reactions

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Other Warnings and Precautions

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Adverse Cerebrovascular Events, including Stroke, in Geriatric Patients with Dementia-related Psychosis

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Potential for Dosing and Medication Errors

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Neuroleptic Malignant Syndrome

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Tardive Dyskinesia

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Metabolic Changes

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Hyperglycemia and Diabetes Mellitus

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Dyslipidemia

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Weight Gain

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Pathological Gambling and Other Compulsive Behaviors

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Orthostatic Hypotension

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Falls

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Leukopenia, Neutropenia, and Agranulocytosis

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Seizures

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Cognitive and Motor Impairment

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Body Temperature Regulation

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Suicide

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Dysphagia

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Phenylketonuria

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Skin Irritation associated with Abilify MyCite® Wearable Sensor

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Specific Populations

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Pregnancy

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Lactation

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Pediatric Use

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Geriatric Use

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Pharmacogenomics and Poor CYP2D6 Metabolizers

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Common Adverse Effects

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Drug Interactions

Drug Interactions

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Drugs Affecting Hepatic Microsomal Enzymes

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Ketoconazole and Other CYP3A4 Inhibitors

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Quinidine and Other CYP2D6 Inhibitors

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Carbamazepine and Other CYP3A4 Inducers

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Drugs Metabolized by Hepatic Microsomal Enzymes

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Anticholinergic Agents

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Hypotensive Agents

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Lorazepam and Other Benzodiazepines

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Alcohol

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Dextromethorphan

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Escitalopram

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Famotidine

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Fluoxetine, Paroxetine, and Sertraline

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Lamotrigine

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Lithium

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Omeprazole

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Valproate

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Venlafaxine

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Warfarin

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Advice to Patients

Advice to Patients

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Aripiprazole Tablets with Sensor

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Preparations

Preparations

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ARIPiprazole

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ARIPiprazole Lauroxil

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Common general statement Elements

Additional Information

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2020, Selected Revisions April 29, 2019. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

Quelle

AHFS Drug Information