Monograph: azaCITIDine

azaCITIDine

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Full Title

azaCITIDine

Generic Name

azaCITIDine

Chemical Name

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INV Number

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Synonym

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Classification

CAS Number

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Introduction

Introduction

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Description

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Uses

Uses

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Myelodysplastic Syndrome

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Acute Myelogenous Leukemia

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Off-label Determinations for Oncology

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Clinical Trial Summary

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Newly Diagnosed Acute Myelogenous Leukemia (AML) with Multilineage Dysplasia (previously classified as refractory anemia with excessive blasts in transformation [ RAEB-t])

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Untreated Acute Myelogenous Leukemia in elderly (>60 years old) who are not eligible to receive standard induction therapy

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Discussion

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Dosage and Administration

Dosage and Administration

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Administration

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Subcutaneous Administration

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Reconstitution

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IV Administration

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Reconstitution and Dilution

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General Dosage

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Myelodysplastic Syndrome

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Acute Myelogenous Leukemia

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Dosage Modification for Hematologic Toxicity

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Table 1. Dosage Modification for Hematologic Toxicity (if baseline leukocyte count is at least 3000/mm3, ANC is at least 1500/mm3, and platelet count is at least 75,000/mm3)

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Table 2. Dosage Modification for Hematologic Toxicity (if baseline leukocyte count is less than 3000/mm3, ANC is less than 1500/mm3, or platelet count is less than 75,000/mm3)

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Dosage Modification for Renal Impairment and Serum Electrolyte Disturbances

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Special Populations

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Cautions

Cautions

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Contraindications

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Warnings/Precautions

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Warnings

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Fetal/Neonatal Morbidity and Mortality

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Major Toxicities

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Hepatotoxicity

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Renal Toxicity

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General Precautions

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Hematologic Effects

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Specific Populations

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Pregnancy

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Lactation

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Pediatric Use

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Geriatric Use

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Hepatic Impairment

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Renal Impairment

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Common Adverse Effects

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Drug Interactions

Drug Interactions

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Advice to Patients

Advice to Patients

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Preparations

Preparations

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azaCITIDine

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Common general statement Elements

Additional Information

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2020, Selected Revisions May 11, 2011. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

† Use is not currently included in the labeling approved by the US Food and Drug Administration.

Quelle

AHFS Drug Information