Monograph: DULoxetine Hydrochloride

DULoxetine Hydrochloride

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Full Title

DULoxetine Hydrochloride

Generic Name

DULoxetine Hydrochloride

Chemical Name

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INV Number

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Classification

CAS Number

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Introduction

Introduction

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Description

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Uses

Uses

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Major Depressive Disorder

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Generalized Anxiety Disorder

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Neuropathic Pain

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Fibromyalgia

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Stress Urinary Incontinence

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Dosage and Administration

Dosage and Administration

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Administration

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Dosage

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Major Depressive Disorder

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Generalized Anxiety Disorder

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Neuropathic Pain

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Fibromyalgia

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Stress Urinary Incontinence

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Special Populations

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Treatment of Pregnant Women during the Third Trimester

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Cautions

Cautions

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Contraindications

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Warnings/Precautions

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Warnings

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Worsening of Depression and Suicidality Risk

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Other Warnings and Precautions

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Hepatic Effects

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Orthostatic Hypotension and Syncope

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Serotonin Syndrome

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Abnormal Bleeding

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Withdrawal Effects

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Activation of Mania/Hypomania

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Seizures

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Blood Pressure

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Clinically Important Drug Interactions

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Hyponatremia/Syndrome of Inappropriate Antidiuretic Hormone Secretion

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Concomitant Illnesses

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Controlled Narrow-Angle Glaucoma

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Urinary Hesitation and Retention

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Specific Populations

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Pregnancy

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Lactation

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Pediatric Use

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Geriatric Use

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Hepatic Impairment

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Renal Impairment

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Common Adverse Effects

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Drug Interactions

Drug Interactions

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Drugs Metabolized by Hepatic Microsomal Enzymes

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Drugs Affecting Hepatic Microsomal Enzymes

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Drugs Affecting Hemostasis

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Drugs that Affect Gastric Acidity

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Alcohol

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Antihypertensive Agents

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Benzodiazepines

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CNS-active Drugs

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5-HT1 Receptor Agonists (“Triptans”)

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Monoamine Oxidase (MAO) Inhibitors

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Selective Serotonin-reuptake Inhibitors and Selective Serotonin- and Norepinephrine-reuptake Inhibitors

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Serotonergic Drugs

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Smoking

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Theophylline

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Thioridazine

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Advice to Patients

Advice to Patients

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Preparations

Preparations

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DULoxetine Hydrochloride

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Common general statement Elements

Additional Information

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2020, Selected Revisions January 1, 2010. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

† Use is not currently included in the labeling approved by the US Food and Drug Administration.

Quelle

AHFS Drug Information