Monograph: Aliskiren Hemifumarate

Aliskiren Hemifumarate

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Full Title

Aliskiren Hemifumarate

Generic Name

Aliskiren Hemifumarate; Aliskiren Hemifumarate and Hydrochlorothiazide

Chemical Name

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INV Number

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Synonym

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Classification

CAS Number

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Introduction

Introduction

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Description

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Uses

Uses

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Hypertension in Adults

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Hypertension in Pediatric Patients

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Table 1. Dosing Groups in Dose-Response Trial Phase

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Table 2. Daily Dosage by Weight in Extension Study

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Dosage and Administration

Dosage and Administration

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General

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Blood Pressure Monitoring and Treatment Goals

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Administration

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Dosage

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Hypertension in Pediatric Patients

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Aliskiren Therapy

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Hypertension in Adults

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Aliskiren Therapy

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Aliskiren/Hydrochlorothiazide Fixed-combination Therapy

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Special Populations

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Cautions

Cautions

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Contraindications

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Warnings/Precautions

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Warnings

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Fetal/Neonatal Morbidity and Mortality

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Other Warnings/Precautions

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Use in Combination with Angiotensin-converting Enzyme Inhibitors or Angiotensin II Receptor Antagonists

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Use of Fixed Combinations

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Sensitivity Reactions

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Hypotension

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Renal Effects

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Hyperkalemia

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Cyclosporine or Itraconazole Interaction

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Specific Populations

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Pregnancy

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Lactation

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Pediatric Use

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Geriatric Use

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Renal Impairment

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Common Adverse Effects

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Drug Interactions

Drug Interactions

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Drugs Affecting or Metabolized by Hepatic Microsomal Enzymes

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Drugs Affecting Transport Systems

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Drugs that Increase Serum Potassium Concentration

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Drugs that Block the Renin-Angiotensin System

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Irbesartan

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Ramipril

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Valsartan

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Antidiabetic Agents

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Metformin

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Pioglitazone

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Antifungal Agents

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Itraconazole

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Ketoconazole

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Antilipemic Agents

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Atorvastatin

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Fenofibrate

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Lovastatin

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Atenolol

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Calcium-channel Blocking Agents

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Amlodipine

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Verapamil

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Cimetidine

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Cyclosporine

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Digoxin

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Diuretics

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Furosemide

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Hydrochlorothiazide

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Fruit Juices

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Isosorbide Mononitrate

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Nonsteroidal Anti-inflammatory Agents

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Celecoxib

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Rifampin

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Warfarin

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Pharmacokinetics

Pharmacokinetics

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Absorption

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Bioavailability

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Onset

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Food

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Special Populations

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Distribution

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Extent

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Plasma Protein Binding

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Elimination

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Metabolism

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Elimination Route

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Half-life

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Special Populations

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Advice to Patients

Advice to Patients

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Preparations

Preparations

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Aliskiren Hemifumarate

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Aliskiren Hemifumarate Combinations

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Common general statement Elements

Additional Information

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2020, Selected Revisions December 2, 2019. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

Quelle

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