Monograph: Deferasirox

Deferasirox

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Full Title

Deferasirox

Generic Name

Deferasirox

Chemical Name

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INV Number

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Synonym

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Classification

CAS Number

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Introduction

Introduction

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Description

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Uses

Uses

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Chronic Iron Overload

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Dosage and Administration

Dosage and Administration

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General

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Restricted Drug Program

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Administration

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Oral Administration

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Dosage

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Chronic Iron Overload

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Dosage Modification for Adverse Renal Effects

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Dosage Modification for Adverse Hepatic Effects

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Dosage Modification for Concomitant Use of Cholestyramine or Uridine 5'-Diphosphate Glucuronosyltransferase (UGT) Inducers

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Special Populations

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Cautions

Cautions

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Contraindications

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Warnings/Precautions

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Warnings

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Renal Effects

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Hepatic Effects

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GI Effects

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Cytopenias

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Comorbid Conditions

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Ocular and Otic Effects

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Sensitivity Reactions

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Hypersensitivity Reactions

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General Precautions

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Dermatologic Effects

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Adequate Patient Monitoring

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Specific Populations

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Pregnancy

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Lactation

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Pediatric Use

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Geriatric Use

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Hepatic Impairment

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Renal Impairment

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Common Adverse Effects

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Drug Interactions

Drug Interactions

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Drugs Metabolized by Hepatic Microsomal Enzymes

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Drugs Affecting Uridine 5'-Diphosphate Glucuronosyltransferase Enzymes

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Drugs with Ulcerogenic or Hemorrhagic Effects

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Aluminum-containing Antacids

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Cholestyramine

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Iron-chelating Agents

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Pharmacokinetics

Pharmacokinetics

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Absorption

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Bioavailability

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Food

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Special Populations

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Distribution

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Extent

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Plasma Protein Binding

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Elimination

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Metabolism

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Elimination Route

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Half-life

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Special Populations

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Advice to Patients

Advice to Patients

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Preparations

Preparations

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Deferasirox

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Common general statement Elements

Additional Information

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2020, Selected Revisions February 1, 2011. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

Quelle

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