Monograph: Deutetrabenazine

Deutetrabenazine

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Full Title

Deutetrabenazine

Generic Name

Deutetrabenazine

Chemical Name

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INV Number

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Classification

CAS Number

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Introduction

Introduction

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Description

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Uses

Uses

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Huntington’s Chorea

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Tardive Dyskinesia

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Tourette's Syndrome

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Dosage and Administration

Dosage and Administration

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General

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Restricted Distribution

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Administration

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Dosage

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Huntington's Chorea

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Tardive Dyskinesia

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Transferring Patients from Tetrabenazine to Deutetrabenazine

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Table 1. Initial Dosage Recommendations for Adults Being Transferred from Tetrabenazine to Deutetrabenazine Therapy.1

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Special Populations

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Hepatic Microsomal Enzyme Considerations

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Cautions

Cautions

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Contraindications

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Warnings/Precautions

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Warnings

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Depression and Suicidality in Patients with Huntington's Disease

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Other Warnings and Precautions

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Clinical Worsening and Adverse Effects in Patients with Huntington's Disease

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Prolongation of QT Interval

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Neuroleptic Malignant Syndrome

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Akathisia, Agitation, and Restlessness

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Parkinsonism in Patients with Huntington's Disease

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Sedation and Somnolence

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Hyperprolactinemia

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Binding to Melanin-containing Tissues

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Specific Populations

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Pregnancy

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Lactation

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Pediatric Use

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Geriatric Use

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Renal Impairment

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Hepatic Impairment

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Poor CYP2D6 Metabolizers

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Common Adverse Effects

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Drug Interactions

Drug Interactions

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Drugs Affecting Hepatic Microsomal Enzymes

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Drugs that Prolong QT Interval

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Alcohol and Other CNS Depressants

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Antipsychotic Agents and Other Dopamine Antagonists

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Monoamine Oxidase Inhibitors

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Reserpine

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Tetrabenazine and Valbenazine

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Advice to Patients

Advice to Patients

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Preparations

Preparations

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Deutetrabenazine

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Common general statement Elements

Additional Information

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2020, Selected Revisions May 7, 2018. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

† Use is not currently included in the labeling approved by the US Food and Drug Administration.

Quelle

AHFS Drug Information