Monograph: Acalabrutinib

Acalabrutinib

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Full Title

Acalabrutinib

Generic Name

Acalabrutinib

Chemical Name

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INV Number

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Classification

CAS Number

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Introduction

Introduction

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Description

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Uses

Uses

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Mantle Cell Lymphoma

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Dosage and Administration

Dosage and Administration

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General

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Restricted Distribution

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Administration

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Concomitant Use with Drugs Affecting Gastric Acidity

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Dosage

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Mantle Cell Lymphoma

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Dosage Modification for Toxicity

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Table 1: Recommended Dosage Modifications for Acalabrutinib Toxicity

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Concomitant Use with Drugs Affecting Hepatic Microsomal Enzymes

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Special Populations

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Cautions

Cautions

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Contraindications

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Warnings/Precautions

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Hemorrhage

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Infectious Complications

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Myelosuppression

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Development of Second Primary Malignancy

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Atrial Fibrillation and Flutter

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Fetal/Neonatal Morbidity and Mortality

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Specific Populations

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Pregnancy

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Lactation

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Pediatric Use

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Geriatric Use

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Hepatic Impairment

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Renal Impairment

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Common Adverse Effects

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Drug Interactions

Drug Interactions

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Drugs Affecting Hepatic Microsomal Enzymes

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Inhibitors of CYP3A

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Inducers of CYP3A

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Drugs Metabolized by Hepatic Microsomal Enzymes

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Substrates of Breast Cancer Resistance Protein

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Drugs Affecting Gastric Acidity

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Proton-pump Inhibitors

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Histamine H2-receptor Antagonists

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Antacids

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Anticoagulants and Antiplatelet Agents

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Advice to Patients

Advice to Patients

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Preparations

Preparations

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Acalabrutinib

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Common general statement Elements

Additional Information

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2020, Selected Revisions October 8, 2018. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

Quelle

AHFS Drug Information