Monograph: Amiodarone Hydrochloride

Amiodarone Hydrochloride

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Full Title

Amiodarone Hydrochloride

Generic Name

Amiodarone Hydrochloride

Chemical Name

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INV Number

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Synonym

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Classification

CAS Number

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Introduction

Introduction

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Uses

Uses

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Ventricular Arrhythmias

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Life-Threatening Ventricular Arrhythmias and Advanced Cardiovascular Life Support

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Shock-Resistant Ventricular Fibrillation or Pulseless Ventricular Tachycardia

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Monomorphic and Polymorphic Ventricular Tachycardia

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Prevention of Ventricular Arrhythmias and Death Associated with Cardiac Arrest

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Primary Prevention

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Secondary Prevention

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Combination Antiarrhythmic Regimens

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Other Ventricular Arrhythmias

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Supraventricular Tachyarrhythmias

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Atrial Fibrillation and Flutter

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Paroxysmal Supraventricular Tachycardia

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Atrial Tachycardia

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Junctional Tachycardia

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Bradycardia-Tachycardia Syndrome

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Angina

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Hypertrophic Cardiomyopathy

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Dosage and Administration

Dosage and Administration

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Reconstitution and Administration

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Oral Administration

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IV Infusion

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Dosage

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Life-threatening Ventricular Arrhythmias in Adults

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Oral Dosage

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Parenteral Dosage

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Supraventricular Arrhythmias in Adults

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Pediatric Dosage

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Oral Dosage

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Parenteral Dosage

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Conversion from IV to Oral Dosage

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Dosage in Renal and Hepatic Impairment

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Cautions

Cautions

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Pulmonary Effects

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Hepatic Effects

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Arrhythmogenic Effects

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Nervous System Effects

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Thyroid Effects

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GI Effects

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Ocular Effects

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Local, Dermatologic, and Sensitivity Reactions

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Cardiovascular Effects

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Effects on Cardiac Conduction and Sinus Node Function

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Hematologic Effects

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Other Adverse Effects

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Precautions and Contraindications

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Pediatric Precautions

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Geriatric Precautions

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Mutagenicity and Carcinogenicity

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Pregnancy, Fertility, and Lactation

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Pregnancy

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Fertility

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Lactation

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Drug Interactions

Drug Interactions

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Drugs Affecting the QT Interval

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Drugs with P-Glycoprotein-mediated Clearance

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Drugs, Foods, and Dietary or Herbal Supplements Affecting Hepatic Microsomal Enzymes

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Antiarrhythmic Agents

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Flecainide

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Procainamide

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Quinidine

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Lidocaine

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HIV Protease Inhibitors

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Histamine H2-Receptor Antagonists

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Histamine H1-Receptor Antagonists

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Cyclosporine

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HMG-CoA Reductase Inhibitors (Statins)

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Rifampin

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St. John’s Wort (Hypericum perforatum)

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Other Drugs Affecting Hepatic Microsomal Enzymes

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Grapefruit Juice

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Phenytoin

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Anticoagulants

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Cardiac Glycosides

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Other Cardiovascular Drugs

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General Anesthetics

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HCV Antivirals

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Cholestyramine Resin

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Agalsidase Beta

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Acute Toxicity

Acute Toxicity

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Pathogenesis

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Manifestation

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Treatment

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Pharmacology

Pharmacology

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Antiarrhythmic and Electrophysiologic Effects

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Effects on Cardiac Conduction and Refractoriness

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Effects on Sinus Node

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Effects on His-Purkinje System

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Effects on Accessory AV Pathways and Reentry Mechanisms

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Antiadrenergic Effects

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Arrhythmogenic Effects

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Cardiovascular Effects

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Thyroid Effects

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Other Effects

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Pharmacokinetics

Pharmacokinetics

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Absorption

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Distribution

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Elimination

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Chemistry and Stability

Chemistry and Stability

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Chemistry

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Stability

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Preparations

Preparations

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Amiodarone Hydrochloride

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2020, Selected Revisions November 14, 2016. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

† Use is not currently included in the labeling approved by the US Food and Drug Administration.

Quelle

AHFS Drug Information