Monograph: Abemaciclib
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Abemaciclib
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Full Title
Abemaciclib
Generic Name
Abemaciclib
Chemical Name
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INV Number
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Classification
CAS Number
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Introduction
Introduction
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...Description
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...Uses
Uses
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Breast Cancer
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Initial Therapy for Advanced Breast Cancer
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Previously Treated Advanced Breast Cancer
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Combination Therapy
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Monotherapy
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...Dosage and Administration
Dosage and Administration
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General
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Administration
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Dosage
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Breast Cancer
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Initial Therapy for Advanced Breast Cancer
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Previously Treated Advanced Breast Cancer
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Dosage Modification for Toxicity
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Table 1: Dosage Modifications for Abemaciclib Toxicity
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Hematologic Toxicity
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Diarrhea
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Hepatic Toxicity
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Interstitial Lung Disease/Pneumonitis
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Other Toxicity
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Dosage Modification with Concomitant Drugs or Foods Affecting Hepatic Microsomal Enzymes
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Special Populations
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...Cautions
Cautions
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Contraindications
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Warnings/Precautions
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Diarrhea
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Neutropenia
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Interstitial Lung Disease/Pneumonitis
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Hepatic Toxicity
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Thromboembolic Events
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Fetal/Neonatal Morbidity and Mortality
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Impairment of Fertility
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Specific Populations
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Pregnancy
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Lactation
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Pediatric Use
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Geriatric Use
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Hepatic Impairment
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Renal Impairment
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Common Adverse Effects
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...Drug Interactions
Drug Interactions
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Drugs and Foods Affecting Hepatic Microsomal Enzymes
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Inhibitors of CYP3A
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Inducers of CYP3A
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Drugs Affected by Transport Systems
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Anastrozole
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Exemestane
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Fulvestrant
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Letrozole
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Loperamide
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...Advice to Patients
Advice to Patients
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...Preparations
Preparations
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Abemaciclib
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...Common general statement Elements
Additional Information
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...References
References
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...Copyright
AHFS® Drug Information. © Copyright, 1959-2020, Selected Revisions April 13, 2020. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.
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