Monograph: Abemaciclib

Abemaciclib

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Full Title

Abemaciclib

Generic Name

Abemaciclib

Chemical Name

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INV Number

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Classification

CAS Number

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Introduction

Introduction

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Description

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Uses

Uses

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Breast Cancer

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Initial Therapy for Advanced Breast Cancer

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Previously Treated Advanced Breast Cancer

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Combination Therapy

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Monotherapy

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Dosage and Administration

Dosage and Administration

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General

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Administration

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Dosage

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Breast Cancer

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Initial Therapy for Advanced Breast Cancer

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Previously Treated Advanced Breast Cancer

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Dosage Modification for Toxicity

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Table 1: Dosage Modifications for Abemaciclib Toxicity

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Hematologic Toxicity

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Diarrhea

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Hepatic Toxicity

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Interstitial Lung Disease/Pneumonitis

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Other Toxicity

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Dosage Modification with Concomitant Drugs or Foods Affecting Hepatic Microsomal Enzymes

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Special Populations

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Cautions

Cautions

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Contraindications

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Warnings/Precautions

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Diarrhea

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Neutropenia

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Interstitial Lung Disease/Pneumonitis

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Hepatic Toxicity

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Thromboembolic Events

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Fetal/Neonatal Morbidity and Mortality

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Impairment of Fertility

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Specific Populations

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Pregnancy

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Lactation

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Pediatric Use

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Geriatric Use

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Hepatic Impairment

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Renal Impairment

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Common Adverse Effects

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Drug Interactions

Drug Interactions

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Drugs and Foods Affecting Hepatic Microsomal Enzymes

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Inhibitors of CYP3A

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Inducers of CYP3A

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Drugs Affected by Transport Systems

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Anastrozole

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Exemestane

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Fulvestrant

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Letrozole

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Loperamide

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Advice to Patients

Advice to Patients

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Preparations

Preparations

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Abemaciclib

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Common general statement Elements

Additional Information

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2020, Selected Revisions April 13, 2020. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

Quelle

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