Monograph: Methadone Hydrochloride

Methadone Hydrochloride

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Full Title

Methadone Hydrochloride

Generic Name

Methadone Hydrochloride

Classification

CAS Number

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Introduction

Introduction

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Uses

Uses

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Pain

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Detoxification and Maintenance of Opiate Dependence

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Neonatal Opiate Withdrawal

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Dosage and Administration

Dosage and Administration

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Administration

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Restricted Distribution

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Dosage

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Pain

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Parenteral Dosage

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Table 1. Conversion of Oral Morphine Sulfate to IV Methadone Hydrochloride (for Chronic Administration)222

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Table 2. Conversion of Parenteral Morphine Sulfate to IV Methadone Hydrochloride (for Chronic Administration)

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Oral Dosage

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Table 3. Conversion of Oral Morphine Sulfate to Oral Methadone Hydrochloride (for Chronic Administration)217222

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Detoxification and Maintenance of Opiate Dependence

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Detoxification

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Maintenance

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Neonatal Opiate Withdrawal

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Cautions

Cautions

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Pediatric Precautions

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Pregnancy and Lactation

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Pregnancy

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Lactation

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Drug Interactions

Drug Interactions

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Drugs Affecting Hepatic Microsomal Enzymes

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Alcohol

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Anticonvulsants

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Antidepressants

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Antifungals

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Antimycobacterials

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Antiretrovirals

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Abacavir

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Atazanavir

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Darunavir

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Delavirdine

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Didanosine

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Efavirenz

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Elvitegravir, Cobicistat, Tenofovir, and Emtricitabine

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Etravirine

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Fosamprenavir

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Indinavir

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Lopinavir

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Maraviroc

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Nelfinavir

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Nevirapine

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Raltegravir

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Rilpivirine

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Ritonavir

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Saquinavir

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Stavudine

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Tenofovir

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Tipranavir

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Zidovudine

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Macrolide Antibiotics

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Smoking

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St. John’s Wort

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Benzodiazepines and Other CNS Depressants.

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Drugs Associated with Serotonin Syndrome

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Drugs that Prolong QT Interval

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Risperidone

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Pharmacology

Pharmacology

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Pharmacokinetics

Pharmacokinetics

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Absorption

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Distribution

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Elimination

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Chemistry and Stability

Chemistry and Stability

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Chemistry

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Stability

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Laboratory Test Interference

Laboratory Test Interferences

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Preparations

Preparations

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Methadone Hydrochloride

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Common general statement Elements

Additional Information

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2020, Selected Revisions July 24, 2020. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

† Use is not currently included in the labeling approved by the US Food and Drug Administration.

Quelle

AHFS Drug Information