Monograph: Remifentanil Hydrochloride

Remifentanil Hydrochloride

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Full Title

Remifentanil Hydrochloride

Generic Name

Remifentanil Hydrochloride

Chemical Name

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INV Number

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Classification

CAS Number

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Introduction

Introduction

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Description

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Uses

Uses

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General Anesthesia

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Monitored Anesthesia Care

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Dosage and Administration

Dosage and Administration

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General

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Premedication

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Concomitant Anesthetics

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Discontinuance of Therapy

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Administration

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IV Administration

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Reconstitution

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Dilution

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Table 1. Reconstitution and Dilution of Remifentanil Powder for Injection1

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Rate of Administration

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Table 2. IV Infusion Rates Required to Administer Remifentanil at Usual Recommended Dosages as a 20-, 25-, 50-, or 250-mcg/mL Solution1

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Dosage

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General Anesthesia (General Dosage) in Pediatric Patients

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Maintenance of General Anesthesia in Neonates and Infants Up to 2 Months of Age

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Maintenance of General Anesthesia in Children 1–12 Years of Age

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General Anesthesia (General Dosage) in Adults

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Induction of General Anesthesia

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Maintenance of General Anesthesia

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Analgesia in the Immediate Postoperative Period

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General Anesthesia for Coronary Artery Bypass Surgery in Adults

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Induction of Anesthesia for Coronary Artery Bypass Surgery

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Maintenance of Anesthesia for Coronary Artery Bypass Surgery

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Analgesia in the Immediate Period After Coronary Artery Bypass Surgery

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Monitored Anesthesia Care in Adults

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As Analgesic Component of Local or Regional (Nerve Block) Anesthesia

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Special Populations

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Geriatric Patients

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Obese Patients

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Cautions

Cautions

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Contraindications

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Warnings/Precautions

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Warnings

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Supervised Administration

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Discontinuance of Therapy

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Respiratory Depression

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Use for Postoperative Analgesia in Conjunction with Benzodiazepines or Other CNS Depressants

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Musculoskeletal Effects

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Adrenal Insufficiency

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General Precautions

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Cardiovascular Effects

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Intraoperative Awareness

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Postoperative Analgesia

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Induction of Anesthesia

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Obesity

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Hypogonadism

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Specific Populations

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Pregnancy

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Lactation

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Pediatric Use

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Geriatric Use

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Hepatic Impairment

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Renal Impairment

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Common Adverse Effects

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Drug Interactions

Drug Interactions

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Benzodiazepines and Other CNS Depressants

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Midazolam

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Temazepam

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Drugs Associated with Serotonin Syndrome

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Anesthetics

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Antimuscarinics

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Cholinesterase Inhibitors

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Esmolol

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Neuromuscular Blocking Agents

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Pharmacokinetics

Pharmacokinetics

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Absorption

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Onset

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Duration

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Plasma Concentrations

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Special Populations

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Distribution

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Extent

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Plasma Protein Binding

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Special Populations

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Elimination

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Metabolism

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Elimination Route

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Half-life

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Special Populations

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Advice to Patients

Advice to Patients

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Preparations

Preparations

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Remifentanil Hydrochloride

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Common general statement Elements

Additional Information

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2020, Selected Revisions July 24, 2020. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

Quelle

AHFS Drug Information