Monograph: Pregabalin

Pregabalin

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Full Title

Pregabalin

Generic Name

Pregabalin

Chemical Name

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INV Number

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Classification

Introduction

Introduction

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Description

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Uses

Uses

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Seizure Disorders

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Neuropathic Pain

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Postherpetic Neuralgia

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Diabetic Neuropathy

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Neuropathic Pain Associated with Spinal Cord Injury

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Other Types of Neuropathic Pain

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Fibromyalgia

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Dosage and Administration

Dosage and Administration

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Administration

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Table 1. Dose Conversion from Conventional to Extended-release Pregabalin15

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Dosage

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Seizure Disorders

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Neuropathic Pain

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Postherpetic Neuralgia

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Diabetic Neuropathy

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Neuropathic Pain Associated with Spinal Cord Injury

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Fibromyalgia

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Special Populations

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Table 2. Dosage Adjustment of Pregabalin Conventional Preparations in Patients with Renal Impairment15101316

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Table 3. Dosage Adjustment of Pregabalin Extended-release Tablets in Patients with Renal Impairment15

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Cautions

Cautions

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Contraindications

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Warnings/Precautions

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Sensitivity Reactions

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Angioedema

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Hypersensitivity Reactions

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Suicidality Risk

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Respiratory Depression

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Dizziness and Somnolence

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Discontinuance of Therapy

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Peripheral Edema

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Weight Gain

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Carcinogenicity

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Ocular Effects

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Creatine Kinase Elevations

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Thrombocytopenia

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PR Interval Prolongation

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Abuse Potential and Dependence

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Specific Populations

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Pregnancy

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Lactation

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Pediatric Use

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Geriatric Use

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Renal Impairment

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Common Adverse Effects

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Drug Interactions

Drug Interactions

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Drugs Affecting Hepatic Microsomal Enzymes

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Drugs that Cause Constipation

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Protein-bound Drugs

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Alcohol

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Angiotensin-converting Enzyme Inhibitors

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Anticonvulsants

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Antidiabetic Agents

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CNS Depressants

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Erythromycin

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Furosemide

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Lorazepam

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Opiates

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Oxycodone

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Oral Contraceptives

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Advice to Patients

Advice to Patients

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Preparations

Preparations

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Pregabalin

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Common general statement Elements

Additional Information

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2020, Selected Revisions December 3, 2020. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

† Use is not currently included in the labeling approved by the US Food and Drug Administration.

Quelle

AHFS Drug Information