Monograph: cloZAPine

cloZAPine

Die Inhalte stehen nur registrierten Benutzern zur Verfügung.

Sie sind zum ersten mal hier und möchten die Datenbank 10-Tage kostenlos testen, dann registrieren Sie sich einmalig. Nach der Registrierung melden Sie sich mit Ihrem Benutzernamen und Passwort an.

Sie sind bereits bei DrugBase registriert und möchten diese Datenbank 10-Tage kostenlos und unverbindlich testen? Dann melden Sie sich mit Ihren Zugangsdaten an und wählen Sie anschließend die Datenbank, die Sie testen möchten.

Full Title

cloZAPine

Generic Name

cloZAPine

Chemical Name

...

INV Number

...

Synonym

...

Classification

CAS Number

...

Introduction

Introduction

...

...

...

Uses

Uses

...

Psychotic Disorders

...

Treatment-resistant Schizophrenia

...

Pediatric Considerations

...

Suicide Risk Reduction in Schizophrenia and Schizoaffective Disorder

...

Parkinsonian Syndrome

...

...

Dosage and Administration

Dosage and Administration

...

Administration

...

Restricted Distribution Program

...

Dosage

...

Treatment-resistant Schizophrenia

...

Adult Dosage

...

Pediatric Dosage

...

Duration of Therapy

...

Suicide Risk Reduction

...

Discontinuance of Therapy

...

Reinitiation of Therapy

...

Dosage in Renal and Hepatic Impairment

...

Pharmacogenomics: Dosage in Poor CYP2D6 Metabolizers

...

...

Cautions

Cautions

...

Hematologic Effects

...

Severe Neutropenia

...

Table 1. Clozapine Treatment Recommendations based on ANC Monitoring in the General Patient Population1395400406408

...

Table 2. Clozapine Treatment Recommendations based on ANC Monitoring in Patients with Benign Ethnic Neutropenia (BEN)1395400406408

...

Eosinophilia

...

Other Hematologic Effects

...

Nervous System Effects

...

Seizures

...

Extrapyramidal Reactions

...

Neuroleptic Malignant Syndrome

...

Tardive Dyskinesia

...

Other Nervous System Effects

...

Fever

...

Cardiovascular Effects

...

Myocarditis, Cardiomyopathy, and Mitral Valve Incompetence

...

Thromboembolic Effects

...

Blood Pressure Effects

...

Prolongation of QT Interval

...

Other Cardiovascular Effects

...

Autonomic Nervous System Effects

...

Hepatic Effects

...

Endocrine and Metabolic Effects

...

Weight Gain

...

Hyperglycemia and Diabetes Mellitus

...

Dyslipidemia

...

Hyperprolactinemia

...

Other Endocrine and Metabolic Effects

...

GI Effects

...

GI Hypomotility with Severe Complications

...

Genitourinary Effects

...

Respiratory Effects

...

Dermatologic and Sensitivity Reactions

...

Other Adverse Effects

...

Precautions and Contraindications

...

Cognitive and Motor Impairment

...

Hepatotoxicity

...

Fever

...

Anticholinergic Toxicity

...

Thromboembolic Events

...

Individuals with Phenylketonuria

...

Neuroleptic Malignant Syndrome

...

Metabolic Effects

...

Falls

...

Orthostatic Hypotension, Bradycardia, and Syncope

...

GI Hypomotility with Severe Complications

...

Geriatric Patients with Dementia-related Psychosis

...

Myocarditis, Cardiomyopathy, and Mitral Valve Incompetence

...

Seizures

...

Severe Neutropenia

...

Other Precautions and Contraindications

...

Pediatric Precautions

...

Geriatric Precautions

...

Mutagenicity and Carcinogenicity

...

Pregnancy, Fertility, and Lactation

...

Pregnancy

...

Fertility

...

Lactation

...

...

Drug Interactions

Drug Interactions

...

Drugs Affecting Hepatic Microsomal Enzymes

...

Phenytoin

...

Carbamazepine

...

Selective Serotonin-reuptake Inhibitors

...

Drugs Metabolized by Hepatic Microsomal Enzymes

...

Other Drugs Associated with Neutropenia

...

Drugs Affecting the Seizure Threshold

...

CNS Depressants

...

Benzodiazepines

...

Other CNS-active Agents

...

Drugs that Prolong the QT Interval

...

Drugs with Anticholinergic Activity and Drugs that Decrease GI Peristalsis

...

Hypotensive Agents

...

Smoking

...

...

Chronical Toxicity

Chronic Toxicity

...

...

Acute Toxicity

Acute Toxicity

...

Pathogenesis

...

Manifestation

...

Treatment

...

...

Pharmacology

Pharmacology

...

Nervous System Effects

...

Antidopaminergic Effects

...

Neurophysiologic Effects

...

Adrenergic Effects

...

Anticholinergic Effects

...

Serotonergic Effects

...

Effects on Other Central Neurotransmitters

...

Behavioral Effects in Animals

...

EEG Effects

...

Effects on Sleep

...

Neuroendocrine Effects

...

Other Effects

...

...

Pharmacokinetics

Pharmacokinetics

...

Absorption

...

Distribution

...

Elimination

...

...

Chemistry and Stability

Chemistry and Stability

...

Chemistry

...

Stability

...

...

Preparations

Preparations

...

cloZAPine

...

...

REMS

...

References

References

...

...

Copyright

AHFS® Drug Information. © Copyright, 1959-2020, Selected Revisions November 9, 2020. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

† Use is not currently included in the labeling approved by the US Food and Drug Administration.

Quelle

AHFS Drug Information