Monograph: Celecoxib

Celecoxib

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Full Title

Celecoxib

Generic Name

Celecoxib

Chemical Name

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INV Number

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Classification

CAS Number

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Introduction

Introduction

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Uses

Uses

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Osteoarthritis

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Rheumatoid Arthritis in Adults

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Juvenile Arthritis

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Ankylosing Spondylitis

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Colorectal Polyps

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Pain

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Dysmenorrhea

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Other Uses

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Dosage and Administration

Dosage and Administration

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Administration

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Dispensing and Administration Precautions

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Dosage

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Osteoarthritis

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Rheumatoid Arthritis in Adults

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Juvenile Arthritis

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Ankylosing Spondylitis

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Colorectal Polyps

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Pain and Dysmenorrhea

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Dosage in Renal and Hepatic Impairment

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Cautions

Cautions

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Cardiovascular Effects

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Thrombotic Events

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Rofecoxib Experience

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Celecoxib Experience

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Experience with Other COX-2 Inhibitors

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Experience with Prototypical NSAIAs

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Patients with Elevated Cardiovascular Risk

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Heart Failure

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Cardiovascular Risk Considerations for COX-2 Inhibitors and Prototypical NSAIAs

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Concomitant Aspirin Therapy

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Ongoing Research

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GI Effects

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GI Risk Considerations for COX-2 Inhibitors and Prototypical NSAIAs

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Nervous System Effects

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Respiratory Effects

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Dermatologic and Sensitivity Reactions

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Hematologic Effects

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Renal, Electrolyte, and Genitourinary Effects

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Musculoskeletal Effects

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Ocular and Otic Effects

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Hepatic Effects

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Other Adverse Effects

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Precautions and Contraindications

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Cardiovascular Precautions

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GI Precautions

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Renal Precautions

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Hepatic Precautions

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Other Precautions and Contraindications

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Pediatric Precautions

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Geriatric Precautions

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Mutagenicity and Carcinogenicity

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Pregnancy, Fertility, and Lactation

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Drug Interactions

Drug Interactions

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Drugs Affecting Hepatic Microsomal Enzymes

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Fluconazole

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Warfarin

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Other Drugs Affecting Hepatic Microsomal Enzymes

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Antacids

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Angiotensin-converting Enzyme Inhibitors and Angiotensin II Receptor Antagonists

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Diuretics

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Glyburide

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Lithium

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Methotrexate

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Nonsteroidal Anti-inflammatory Agents

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Acute Toxicity

Acute Toxicity

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Manifestation

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Treatment

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Pharmacology

Pharmacology

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Mechanism of Action

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Anti-inflammatory, Analgesic, and Antipyretic Effects

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Renal Effects

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GI Effects

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Hematologic Effects

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Pharmacokinetics

Pharmacokinetics

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Absorption

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Distribution

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Elimination

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Chemistry and Stability

Chemistry and Stability

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Chemistry

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Stability

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Preparations

Preparations

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Celecoxib

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2020, Selected Revisions November 9, 2020. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

† Use is not currently included in the labeling approved by the US Food and Drug Administration.

Quelle

AHFS Drug Information