Monograph: Montelukast Sodium

Montelukast Sodium

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Full Title

Montelukast Sodium

Generic Name

Montelukast Sodium

Chemical Name

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INV Number

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ATC-Code

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Classification

CAS Number

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Introduction

Introduction

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Uses

Uses

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Bronchospasm

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Asthma

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Mild Persistent Asthma

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Moderate Persistent Asthma

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Severe Persistent Asthma

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Clinical Experience with Leukotriene Modifiers

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Clinical Efficacy of Montelukast

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Concomitant Corticosteroid Therapy

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Exercise-induced Bronchospasm

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Allergic Rhinitis

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Urticaria

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Dosage and Administration

Dosage and Administration

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Administration

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Dosage

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Asthma

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Adult Dosage

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Pediatric Dosage

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Exercise-induced Bronchospasm

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Adult Dosage

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Pediatric Dosage

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Allergic Rhinitis

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Adult Dosage

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Pediatric Dosage

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Dosage in Renal and Hepatic Impairment

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Cautions

Cautions

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Nervous System Effects

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GI Effects

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Hepatic Effects

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Dermatologic and Sensitivity Reactions

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Eosinophilia and Churg-Strauss Syndrome

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Respiratory Effects

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Other Adverse Effects

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Precautions and Contraindications

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Pediatric Precautions

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Geriatric Precautions

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Mutagenicity and Carcinogenicity

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Pregnancy, Fertility, and Lactation

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Pregnancy

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Fertility

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Lactation

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Drug Interactions

Drug Interactions

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Nonsteroidal Anti-inflammatory Agents

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Drugs Affecting Hepatic Microsomal Enzymes

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Phenobarbital

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Theophylline

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Warfarin

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Rifampin

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Antihistamines

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Digoxin

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Estrogen-Progestin Combinations

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Corticosteroids

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Acute Toxicity

Acute Toxicity

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Pathogenesis

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Manifestation

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Treatment

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Pharmacology

Pharmacology

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Anti-inflammatory Effects

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Asthma and Allergic Rhinitis

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Effects on Leukotrienes

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Inhibition of Bronchoconstriction

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Effects on Eosinophils

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Other Effects

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Pharmacokinetics

Pharmacokinetics

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Absorption

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Distribution

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Elimination

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Chemistry and Stability

Chemistry and Stability

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Chemistry

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Stability

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Preparations

Preparations

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Montelukast Sodium

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2021, Selected Revisions December 21, 2020. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

† Use is not currently included in the labeling approved by the US Food and Drug Administration.

Quelle

AHFS Drug Information