Monograph: Oliceridine Fumarate
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Oliceridine Fumarate
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Full Title
Oliceridine Fumarate
Generic Name
Oliceridine
Chemical Name
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Classification
28: Central Nervous System Agents
> 28:08: Analgesics and Antipyretics
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28:08.08: Opiate Agonists
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Introduction
Introduction
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Uses
Uses
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Oliceridine fumarate has the following uses:
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Oliceridine fumarate has the following limitations of use:
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...Dosage and Administration
Dosage and Administration
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General
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Injection:
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Dosage
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Adults
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Dosage and Administration
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...Cautions
Cautions
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Contraindications
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Warnings/Precautions
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Addiction, Abuse, and Misuse
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Life-threatening Respiratory Depression
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Neonatal Opioid Withdrawal Syndrome
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Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants
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Potential for QT Prolongation with Daily Doses Exceeding 27 mg
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Risk of Use in Patients with Decreased Cytochrome P-450 2D6 Function or Concomitant Use or Discontinuation with Cytochrome P-450 3A4 Inhibitors and Inducers
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Risk of Increased Oliceridine Plasma Concentrations
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Risk of Lower than Expected Oliceridine Plasma Concentrations
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Life-threatening Respiratory Depression in Patients with Chronic Pulmonary Disease or in Elderly, Cachectic, or Debilitated Patients
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Patients with Chronic Pulmonary Disease
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Elderly, Cachectic, or Debilitated Patients
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Adrenal Insufficiency
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Severe Hypotension
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Risks of Use in Patients with Increased Intracranial Pressure, Brain Tumors, Head Injury, or Impaired Consciousness
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Risks of Use in Patients with Gastrointestinal Conditions
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Increased Risk of Seizures in Patients with Seizure Disorders
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Withdrawal
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Risks of Driving and Operating Machinery
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Patient-controlled Analgesia (PCA)
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Specific Populations
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Pregnancy
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Lactation
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Females And Males Of Reproductive Potential
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Pediatric Use
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Geriatric Use
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Renal Impairment
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Hepatic Impairment
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Poor Metabolizers of CYP2D6 Substrates
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Common Adverse Effects
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...Drug Interactions
Drug Interactions
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Specific Drugs
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...Mechanism of Action
Actions
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Mechanism of Action
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...Advice to Patients
Advice to Patients
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Serotonin Syndrome
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Constipation
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...Preparations
Preparations
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Oliceridine Fumarate
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...Common general statement Elements
Additional Information
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...References
References
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...Copyright
AHFS® Drug Information. © Copyright, 1959-2021, Selected Revisions December 14, 2020. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.
Quelle
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