Monograph: Bendamustine Hydrochloride

Bendamustine Hydrochloride

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Full Title

Bendamustine Hydrochloride

Generic Name

Bendamustine Hydrochloride

Chemical Name

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INV Number

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Classification

CAS Number

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Introduction

Introduction

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Description

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Uses

Uses

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Chronic Lymphocytic Leukemia

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Non-Hodgkin's Lymphoma

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Rituximab-refractory, Indolent, B-cell Non-Hodgkin's Lymphoma

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Previously Untreated, Indolent Non-Hodgkin's Lymphoma or Mantle Cell Lymphoma

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Relapsed or Refractory Non-Hodgkin's Lymphoma or Mantle Cell Lymphoma

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Dosage and Administration

Dosage and Administration

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Administration

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Reconstitution and Dilution

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Dilution of Bendamustine Hydrochloride Injection Concentrate (Belrapzo®)

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Dilution of Bendamustine Hydrochloride Injection Concentrate (Bendeka®)

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Reconstitution and Dilution of Bendamustine Hydrochloride Lyophilized Powder (Treanda®)

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Dosage

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Adults

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Chronic Lymphocytic Leukemia

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Non-Hodgkin's Lymphoma

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Special Populations

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Cautions

Cautions

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Contraindications

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Warnings/Precautions

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Hematologic Effects

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Infectious Complications

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Infusion Reactions

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Tumor Lysis Syndrome

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Dermatologic Reactions

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Hepatic Toxicity

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Development of Other Malignancies

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Local Effects

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Fetal/Neonatal Morbidity and Mortality

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Specific Populations

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Pregnancy

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Males of Reproductive Potential

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Lactation

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Pediatric Use

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Geriatric Use

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Hepatic Impairment

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Renal Impairment

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Race

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Gender

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Common Adverse Effects

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Drug Interactions

Drug Interactions

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Drugs Affecting Hepatic Microsomal Enzymes

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Drugs Metabolized by Hepatic Microsomal Enzymes

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Drugs that Affect Transport Systems

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Advice to Patients

Advice to Patients

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Preparations

Preparations

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Bendamustine Hydrochloride

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Common general statement Elements

Additional Information

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2021, Selected Revisions August 16, 2021. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

† Use is not currently included in the labeling approved by the US Food and Drug Administration.

Quelle

AHFS Drug Information