Monograph: Fexinidazole

Fexinidazole

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Full Title

Fexinidazole

Generic Name

Fexinidazole

Chemical Name

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Classification

CAS Number

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Introduction

Introduction

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Uses

Uses

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Fexinidazole has the following uses:

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Fexinidazole has the following limitations of use:

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Dosage and Administration

Dosage and Administration

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General

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Dosage

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Pediatric Patients

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Dosage and Administration

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Table 1. Recommended Dosage of Fexinidazole in Pediatric Patients ≥6 Years of Age and Weighing ≥20 kg 1

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Adults

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Dosage and Administration

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Table 2. Recommended Dosage of Fexinidazole in Adults Weighing ≥20 kg 1

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Cautions

Cautions

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Contraindications

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Warnings/Precautions

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Decreased Efficacy in Severe Human African Trypanosomiasis Caused By Trypanosoma Brucei Gambiense

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QT Interval Prolongation

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Neuropsychiatric Adverse Reactions

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Neutropenia

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Potential for Hepatotoxicity

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Risk of Disulfiram-like Reaction Due to Concomitant Use with Alcohol

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Risk of Psychotic Reactions Due to Concomitant Use with Disulfiram

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Specific Populations

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Pregnancy

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Lactation

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Pediatric Use

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Geriatric Use

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Renal Impairment

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Hepatic Impairment

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Common Adverse Effects

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Drug Interactions

Drug Interactions

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Specific Drugs

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Mechanism of Action

Actions and Spectrum

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Mechanism of Action

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Spectrum

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Resistance

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Advice to Patients

Advice to Patients

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Preparations

Preparations

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Fexinidazole

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Common general statement Elements

Additional Information

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2021, Selected Revisions August 9, 2021. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

Quelle

AHFS Drug Information