Monograph: Efavirenz

Efavirenz

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Full Title

Efavirenz

Generic Name

Efavirenz; Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate

Chemical Name

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INV Number

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Classification

CAS Number

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Introduction

Introduction

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Uses

Uses

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Treatment of HIV Infection

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Antiretroviral-naive Adults and Adolescents

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Study 006

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Study 934

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Antiretroviral-experienced Adults

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Study ACTG 364

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Study 073

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Pediatric Patients

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Study AI266922

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Study PACTG 1021

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Study PACTG 382

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Postexposure Prophylaxis following Occupational Exposure to HIV

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Postexposure Prophylaxis following Nonoccupational Exposure to HIV

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Dosage and Administration

Dosage and Administration

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Administration

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Efavirenz Capsules

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Efavirenz Tablets

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Fixed Combinations Containing Efavirenz

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Dosage

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Adult Dosage

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Treatment of HIV Infection

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Treatment of HIV Infection in Patients Receiving Rifampin

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Postexposure Prophylaxis following Occupational Exposure to HIV

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Pediatric Dosage

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Table 1. Efavirenz (Sustiva®) Dosage in Children 3 Months of Age or Older1

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Dosage in Renal and Hepatic Impairment

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Renal Impairment

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Hepatic Impairment

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Cautions

Cautions

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Nervous System Effects and Psychiatric Symptoms

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Dermatologic and Sensitivity Reactions

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Hepatic Effects

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GI Effects

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Cardiovascular and Lipid Effects

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Immune Reconstitution Syndrome

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Adipogenic Effects

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Other Adverse Effects

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Precautions and Contraindications

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Fetal/Neonatal Morbidity and Mortality

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Interactions

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Precautions Related to Nervous System Effects and Psychiatric Symptoms

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Precautions Related to Hepatic Impairment and Hepatic Effects

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Precautions Related to Cardiovascular Effects

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Precautions Related to Use of Fixed Combinations

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Other Precautions

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Pediatric Precautions

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Geriatric Precautions

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Mutagenicity and Carcinogenicity

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Pregnancy, Fertility, and Lactation

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Pregnancy

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Fertility

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Lactation

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Drug Interactions

Drug Interactions

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Drugs Affecting or Metabolized by Hepatic Microsomal Enzymes

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Anticoagulants

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Antifungal Agents

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Fluconazole

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Isavuconazonium

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Itraconazole

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Ketoconazole

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Posaconazole

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Voriconazole

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Antihistamine Drugs

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Antimalarial Agents

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Artemether and Lumefantrine

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Atovaquone and Proguanil

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Antimycobacterial Agents

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Bedaquiline

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Rifabutin

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Rifampin

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Rifapentine

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Antiretroviral Agents

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HIV Entry and Fusion Inhibitors

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Enfuvirtide

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Maraviroc

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HIV Integrase Inhibitors (INSTIs)

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Dolutegravir

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Elvitegravir

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Raltegravir

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HIV Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs)

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HIV Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTIs)

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HIV Protease Inhibitors (PIs)

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Atazanavir

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Darunavir

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Fosamprenavir

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Indinavir

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Lopinavir

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Nelfinavir

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Ritonavir

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Saquinavir

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Tipranavir

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Atovaquone

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Cardiovascular Agents

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Antilipemic Agents

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Atorvastatin

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Lovastatin

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Pitavastatin

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Pravastatin

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Rosuvastatin

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Simvastatin

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Calcium-channel Blocking Agents

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CNS Agents

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Opiates and Opiate Partial Agonists

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Buprenorphine

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Methadone

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Anticonvulsants

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Psychotherapeutic Agents

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Bupropion

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Selective Serotonin-reuptake Inhibitors

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Pimozide

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Sedatives and Hypnotics

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Corticosteroids

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Ergot Alkaloids

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Estrogens and Progestins

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GI Drugs

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HCV Antivirals

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HCV Polymerase Inhibitors

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Sofosbuvir

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Sofosbuvir and Velpatasvir

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HCV Protease Inhibitors

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Simeprevir

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HCV Replication Complex Inhibitors

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Daclatasvir

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Elbasvir and Grazoprevir

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Ledipasvir and Sofosbuvir

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Ombitasvir, Paritaprevir, and Ritonavir

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Immunosuppressive Agents

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Macrolide Antibiotics

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Phosphodiesterase Type 5 Inhibitors

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Avanafil

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Dietary and Herbal Supplements

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St. John’s Wort (Hypericum perforatum)

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Acute Toxicity

Acute Toxicity

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Manifestations

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Treatment

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Pharmacokinetics

Pharmacokinetics

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Absorption

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Distribution

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Elimination

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Chemistry and Stability

Chemistry and Stability

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Chemistry

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Stability

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Spectrum Section

Spectrum

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Retroviruses

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Resistance Section

Resistance

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Cross-resistance

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Mechanism of Action

Mechanism of Action

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Antiviral Effects

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Cytotoxic Effects

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Laboratory Test Interference

Laboratory Test Interferences

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Cannabinoid Assays

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Preparations

Preparations

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Efavirenz

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Efavirenz Combinations

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References

References

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Copyright

AHFS® Drug Information. © Copyright, 1959-2021, Selected Revisions May 15, 2017. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

† Use is not currently included in the labeling approved by the US Food and Drug Administration.

Quelle

AHFS Drug Information