Preservatives

Preservatives

Preservatives by Frequency of Use in Cosmetic Formulations

The use of preservatives for cosmetic purposes is regulated in the EU by the Commission Directive 2007/17/EC of 22 March 2007, amending Council Directive 76/768/EEC, concerning cosmetic products, for the purposes of adapting Annexes III and VI.

eur-lex.europa.eu/Notice.do

The Annex VI of the Council Directive 76/768/EEC can be found under

borealischem.com/pdf/Annex6%20Parts1-2PreservativesList.pdf

In the US preservatives are registered by the FDA.

In Japan the use of preservatives in cosmetics is regulated by the “Standards for Cosmetics” (Ministry of Health and Welfare Notification No.331 of 2000), Appendix 3, see also

www.mhlw.go.jp/english/topics/cosmetics/index.html

The frequency of use of preservatives in the US in 2005 is given in the following table.

Preservative

Frequency of use (2005)

Methylparaben

7866

Propylparaben

6260

Butylparaben

2784

Ethylparaben

2310

Phenoxyethanol

2227

Imidazolidinyl urea

2036

Sodium sulfite

1306

Resorcinol

1176

DMDM hydantoin

1062

Diazolidinyl urea

737

Methylchloroisothiazolinone/methylisothiazolinone 818

699

Sorbic acid/potassium sorbate

639

Benzoic acid/Sodium benzoate

582

Dehydroacetic acid/Sodium dehydroacetate

559

Quaternium-15

515

Isobutylparaben

507

Benzyl alcohol

502

Triclosan

484

Boric acid/sodium borate

353

Iodopropynyl butylcarbamate

195

2-Bromo-2-nitropropane-1,3-diol

187

Sodium methylparaben

160

Salicylic acid

140

Methyldibromo glutaronitrile

115

Formaldehyde

113

Benzalkonium chloride

82

Chlorhexidine digluconate

68

Sodium bisulfite

62

Chlorphenesin

58

Hexamidine isethionate

47

Isopropylparaben

47

Chloroxylenol

44

Chloroacetamide

36

Sodium hydroxymethylglycinate

35

5-Bromo-5-nitro-1,3-dioxane

34

Benzethonium chloride

32

Sodium propylparaben

30

Methenamine

28

o-Phenylphenol/Sodium-o-phenylphenol

28

Phenethyl alcohol

28

Grapefruit Seed Extract

23

Triclocarban

22

Paraformaldehyde

21

Glutaraldehyde (Glutaral)

19

Polymethoxy bicyclic oxazolidine

19

Chlorhexidine dihydrochloride

18

o-Cymen-5-ol

18

Thymol

13

Piroctone olamine

12

Dichlorobenzyl alcohol

11

Chlorhexidine acetate

9

Climbazole

9

Formic acid and salts

7

Hinokitiol

7

Domiphen bromide

6

Phenoxyisopropanol

6

Dichlorophene

5

p-Chloro-m-cresol

5

Phenyl mercuric acetate

5

Thiomersal

5

Undecylenic acid and salts

4

Dimethyloxazolidine

2

Polyaminopropyl biguanide

2

Benzylparaben

1

Chlorhexidine

1

7- Ethylbicyclooxazolidine

1

Total formulations reported

22228

Reference: D. C. Steinberg, 2005 Preservatives use: Frequency reports and registration, Cosmetic and Toiletries magazine 121(7), 65-69 (2006).